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精确的SERS驱动:革命性的治疗药物监测与纳米级的灵敏度

Biqing Chen¹, Jiayin Gao¹, Haizhu Sun¹

¹Department of Gynaecology and Obstetrics, The Second Affiliated Hospital of Harbin Medical University,, Harbin Medical University, Heilongjiang, 150081, PR China.

Mikrochimica acta

|November 18, 2025

概括

表面增强拉曼光谱 (SERS) 为治疗药物监测提供了一种敏感且具有成本效益的方法. 最近的进展侧重于新的基质和策略,以克服信号可重现性和矩阵干扰等挑战,以改善临床结果.

科学领域:

分析化学分析化学
生物医学工程生物医学工程
频谱学是一种光谱学.

背景情况:

对药物和代谢物进行监测对于研究和临床应用至关重要.
表面增强拉曼光谱 (SERS) 是治疗药物监测的一个有希望的技术,因为它的灵敏度,低成本和最小的样本要求.

研究的目的:

审查SERS用于药物监测的最新进展.
突出新型基质设计和提高检测灵敏度和选择性的策略.
讨论基于SERS的药物监测中的挑战和新出现的解决方案.

主要方法:

关于SERS在药物监测中的应用的最新文献的综述.
强调新的基质设计和先进的分析策略.
讨论信号可重现性和生物矩阵干扰等挑战.

主要成果:

新型SERS基板显著提高了检测灵敏度和选择性.
新兴的策略,如数字SERS,丰富,微流体,混合平台和机器学习解决了传统的局限性.
这些方法提高了复杂生物样本的分析性能.

结论:

SERS是治疗药物监测的强大工具.
先进的策略正在克服SERS分析中的关键挑战.
将SERS与其他技术集成,有可能实现个性化治疗和改善临床结果.

关键词:

在纳米尺度上检测药物.医疗点检测 (POCT) 是指在医疗中心进行的检测.在SERS生物传感器.表面增强的拉曼光谱学 (SERS)治疗药物监测 (TDM) 是指对治疗药物进行监测.

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