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慢性炎症性脱髓化多神经病变的认知障碍
Oliver L Steiner1,2,3, Claudia Angela4,5, Elena Krasivskaya4
1Motor and Cognition Group, Department of Neurology, Charité - Universitätsmedizin Berlin, Freie Universität Berlin and Humboldt-Universität zu Berlin, Campus Benjamin Franklin (CBF), Hindenburgdamm 30, 12203, Berlin, Germany. oliver.steiner@charite.de.
认知障碍在慢性炎症性脱髓化多神经病 (CIDP) 中很常见,影响处理速度,执行功能和记忆力. 在CIDP患者中,这些缺陷随着感觉运动障碍的增加而恶化.
科学领域:
- 神经学 神经学
- 神经科学是一个神经科学.
- 临床医学 临床医学
背景情况:
- 认知功能障碍是慢性炎症性脱髓化多神经病 (CIDP) 的已知但不太了解的一个方面.
- 确切影响认知领域及其与CIDP整体临床表现的关系仍然不清楚.
研究的目的:
- 综合比较具有CIDP和没有CIDP的个体的认知概况.
- 在CIDP的关键症状综合体中分析认知缺陷,包括感觉运动障碍,疲劳和情绪.
主要方法:
- 44名被诊断患有CIDP的人接受了广泛的基于计算机的认知测试.
- 临床评估包括感觉运动障碍 (R-ODS),疲劳 (FSMC) 和情绪 (DESC-I).
- 认知表现与33个年龄相匹配的健康对照进行了比较.
主要成果:
- 与对照组相比,患有CIDP的个人表现出明显较差的整体认知表现.
- 在处理速度,执行功能,记忆 (短期和长期) 和视觉构造方面观察到明显的认知缺陷.
- 感官运动障碍被确定为CIDP患者整体认知表现的重要预测因素.
结论:
- 认知障碍,特别是在处理速度,执行功能和记忆方面,是CIDP的一个未被认可的特征.
- 在CIDP中,认知缺陷的严重程度与感觉运动障碍的程度相关.
- CIDP与功能变化有关,这些变化超出了其主要的神经症状.
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