甲状腺过氧化酶抗体和冠状动脉化:来自ELSA-巴西队列研究的结果
Vandrize Meneghini1, William R Tebar1, Giuliano Generoso1
1Center for Clinical and Epidemiological Research, Universidade de São Paulo, Av. Lineu Prestes 2565, 3° andar, CEP 05508-000, São Paulo, Brazil.
Journal of endocrinological investigation
|November 18, 2025
概括
较高的甲状腺过氧化酶抗体 (TPOAb) 水平与冠状动脉化 (CAC) 发生率和进展的风险增加有关. 这些发现表明TPOAb可能在动脉样硬化中发挥作用,独立于甲状腺功能.
科学领域:
- 心脏病学 心脏病学
- 内分泌学 在内分泌学.
- 免疫学 免疫学 免疫学
背景情况:
- 甲状腺过氧化酶抗体 (TPOAb) 与自身免疫性甲状腺疾病有关.
- 在心血管疾病,特别是冠状动脉化 (CAC) 中TPOAb的作用尚未完全理解.
- 调查TPOAb对动脉样硬化的独立贡献对于了解心血管风险至关重要.
研究的目的:
- 探索TPOAb水平与CAC的发生率和进展之间的关联.
- 为了确定TPOAb是否独立于甲状腺功能对CAC有所贡献.
- 分析TPOAb和CAC之间的性别特定关联.
主要方法:
- 来自巴西成年人健康纵向研究 (ELSA-巴西) 队列的3013名参与者的分析.
- 使用连续冠状动脉分数评估事件CAC和CAC进展的评估.
- 使用Poisson和后勤回归模型来评估TPOAb四分位数与CAC结果之间的关联,并对混因素进行调整.
主要成果:
- 较高的TPOAb四分位数 (第三和第四) 与CAC发病率的风险增加显著相关 (IRR为1.38-1.43).
- 这些关联在调整心血管风险因素和甲状腺功能后以及在无甲状腺患者中仍然存在.
- 升高的TPOAb水平也与CAC进展有关 (OR 1.50) 并显示了CAC发病风险的性别特异性差异.
结论:
- 较高的TPOAb水平与在5年内患上CAC的风险更高有关.
- TPOAb可能具有不依赖于甲状腺功能的动脉起作用.
- 这些发现凸显了TPOAb作为评估心血管风险的潜在生物标志物.
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