对于AMPULLAR神经内分泌瘤的内皮切除术后的长期结果
Yoonchan Lee1, Dongwook Oh1, Seung-Mo Hong2
1Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
概括
透视乳头切除术 (EP) 对没有淋巴结转移的囊性神经内分泌瘤 (Amp-NETs) 是安全的. 没有在消极切除边缘的患者中出现复发,支持EP在选定的情况下.
科学领域:
- 胃肠病学 胃肠病学
- 手术瘤学手术瘤学
- 内镜检查是指内镜检查.
背景情况:
- 由于对淋巴结 (LN) 转移和瘤复发的担忧,对于囊性神经内分泌瘤 (Amp-NETs) 的内镜乳头切除术 (EP) 的疗效仍在争论中.
- 这项研究旨在评估Amp-NET患者的长期EP安全性和复发率.
研究的目的:
- 为了评估长期的结果,包括复发和安全性,内皮切除术 (EP) 对于囊神经内分泌瘤 (Amp-NETs).
- 确定无复发生存率 (RFS) 并确定与Amp-NETs EP后复发相关的因素.
主要方法:
- 在2004年至2018年期间接受EP的组织学确认的Amp-NET患者的回顾性审查.
- 包括标准包括瘤大小<3厘米,在成像上没有LN或远程转移的证据.
- 评估的结果是复发,不良事件和无复发生存期 (RFS).
主要成果:
- 包括34名患者,在55.9%的患者中实现了完全切除.
- 在平均68.5个月的随访期间,复发发生在9.1%的患者中,仅在那些有积极切除边际 (20%) 的患者中.
- 在边际阴性患者 (0%) 中没有观察到复发. 早期不良事件 (出血,胰腺炎) 发生在38.2%的患者中,晚期不良事件 (乳头狭窄) 发生在11.8%的患者中,所有这些都通过内镜进行管理.
结论:
- 内镜乳头切除术 (EP) 是一种安全有效的治疗方法,用于小型,差异化良好的没有淋巴结转移的Amp-NET.
- 在边缘阴性患者中没有复发,支持 EP 在精心挑选的病例中.
- 阳性边缘的患者需要密切监测和潜在的进一步手术干预.
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