对高风险的皮肤状细胞癌的周术系统疗法
Kelly M Kimball1, Rachel E Politi2, Kathryn T Shahwan3
1Department of Dermatology, OhioHealth Riverside, Columbus, OH, USA.
American journal of clinical dermatology
|November 18, 2025
概括
高风险的皮肤状细胞癌 (CSCC) 治疗正在通过免疫疗法推进. 编程细胞死亡蛋白/ligand-1 抑制剂在新辅助和辅助环境中表现有前途,可改善患者的治疗结果.
科学领域:
- 在瘤学瘤学.
- 皮肤病学 皮肤病学
- 免疫治疗是一种免疫疗法.
背景情况:
- 皮肤状细胞癌 (CSCC) 的发病率正在增加.
- 高风险的CSCC需要除了手术之外的治疗方法.
- 包括免疫疗法在内的全身疗法正在经手术后的环境中进行研究.
研究的目的:
- 审查新辅助和辅助免疫治疗对高风险CSCC的不断变化的作用.
- 突出免疫疗法在CSCC治疗中的有效性和正在进行的研究.
主要方法:
- 对CSCC的全身疗法的审查,重点是免疫疗法药物,如塞米普利马布,布罗利祖马布和阿特佐利祖马布.
- 在外科手术期间研究新辅助和辅助免疫疗法的研究分析.
- 评估反应率,生存数据和安全概况.
主要成果:
- 免疫疗法,特别是编程细胞死亡蛋白/联体-1 抑制剂,已经彻底改变了先进的CSCC治疗.
- 塞米普利马布在新辅助设置中显示出显著的病理反应率 (64-75%),在辅助设置中改善了生存率.
- 其他药物,如 pembrolizumab 和 atezolizumab 也在调查中.
结论:
- 新辅助和辅助免疫疗法代表高风险CSCC的有前途的治疗选择.
- 需要进一步的研究来优化治疗方案,预测反应者,建立长期数据和研究特殊人群.
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