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弥合多发性硬化症中的中视镜和显微镜尺度:死后脑区块多对比9.4TMRI和组织学量化

Dimitrios G Gkotsoulias¹, Lukas Schönenberger¹, Jochen Leupold²

¹Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB), University of Basel, Basel, Switzerland; Translational Imaging in Neurology Basel, Department of Biomedical Engineering, Faculty of Medicine, University of Basel, Allschwil, Switzerland; Department of Neurology, University Hospital Basel, Basel, Switzerland.

|November 18, 2025

概括

这项研究引入了一个可复制的协议,用于将磁共振成像 (MRI) 和组织学整合到多发性硬化症 (MS) 研究中. 它可以详细地绘制大脑组织微观结构,以更好地了解多发性硬化症的发病过程.

科学领域:

神经科学是一个神经科学.
医疗成像医学成像
病理学病理学病理学

背景情况:

多发性硬化症 (MS) 研究依赖于将组织微观结构与成像数据相关联.
在MS大脑中集成ex vivoMRI和组织学现有的方法可能具有复制和扩展的挑战性.

研究的目的:

提出一个强大,可扩展和可重复的协议,用于对死后多发性硬化症脑组织的MRI和组织学综合分析.
为了使主要病理标记在MS的详细,半定量映射.

主要方法:

从死后的MS脑块获取高分辨率,多对比的9.4TMRI数据.
开发和应用一个定制的,开源的图像处理接口.
强大的组织学和MRI数据的记录,以实现准确的空间相关性.
髓密度,微质细胞和细胞数量的半定量映射.

主要成果:

该协议有助于可复制和可扩展的整合中镜MRI和微观组织学数据.
定制界面可以实现精确的组织学-MRI注册.
成功生成了髓,微质细胞和细胞密度的半定量地图.

结论:

这种集成的MRI-组织学协议为阐明MS病变发生提供了强大的工具.
开源方法促进了可访问性和神经退行性疾病研究的进一步发展.
这些发现支持使用组合成像模式来对MS进行详细的组织微观结构分析.

关键词:

卫生科学卫生科学卫生科学神经科学是一个神经科学.显微镜显微镜是指使用显微镜.

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