二次性低雄性和替代疗法对心血管事件的影响
Vicki Munro1, Jocelyn Law1, Kara Matheson2
1Division of Endocrinology, Department of Medicine, Dalhousie University.
替代疗法 (TRT) 不会增加二次性阴道腺乱 (SHG) 的男性的主要不良心血管事件 (MACE). 然而,未经治疗的SHG与较高的死亡风险有关.
科学领域:
- 内分泌学 在内分泌学.
- 心血管医学 心血管医学
- 在瘤学瘤学.
背景情况:
- 替代疗法 (TRT) 的心血管 (CV) 安全性受到争论.
- 由于下垂体疾病导致的二次性腺缩 (SHG) 需要TRT,但其长期的CV安全性尚不清楚.
研究的目的:
- 为了调查发生主要不良心血管事件 (MACE) 在男性患有垂体腺瘤和SHG的男性患者,有或没有TRT.
主要方法:
- 对408名患有垂体腺瘤的男性患者进行了回顾性队列研究.
- 通过图表审查和登记册收集的关于MACE,TRT和死亡率的数据.
- 分析包括有和没有SHG的患者,以及接受或未接受TRT治疗的患者.
主要成果:
- 两组之间没有发现MACE的显著差异 (没有SHG,接受TRT治疗的SHG,未接受治疗的SHG).
- 腺瘤大小,其他激素缺陷或丸激素水平都没有影响MACE.
- 与治疗的SHG和没有SHG组相比,未治疗的SHG显示死亡风险增加.
结论:
- 在患有下垂体疾病的SHG患者中,TRT与MACE增加无关.
- 未经治疗的SHG可能会增加死亡风险,可能受到年龄和并发症的影响.
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