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所有闪闪发光的都不是黄金:晶体储存细胞瘤呈现为肺部质量

Md Ali Osama¹, Anubhav Pal¹, Moiom H Phom¹

¹Department of Pathology, All India Institute of Medical Sciences, New Delhi, India.

International journal of surgical pathology

|November 18, 2025

概括

结晶储存细胞症 (CSH) 是一种罕见的疾病,涉及免疫球蛋白在细胞中积累. 这一案例凸显了CSH模仿肺部疾病及其与血液恶性瘤的联系.

科学领域:

血液学血液学血液学
肺部病理学肺部病理学
病理学病理学病理学

背景情况:

晶体储存细胞症 (CSH) 是一种罕见的疾病,其特征是免疫球蛋白晶体在细胞内积累.
CSH经常与单克隆性淋巴结核病和淋巴增殖性疾病有关.
肺性CSH可以模仿其他肺部疾病,使诊断复杂化.

研究的目的:

报告一个肺性CSH病例.
强调诊断的挑战和在识别CSH时组织病理学的重要性.
突出CSH与潜在的血液恶性瘤之间的关联.

主要方法:

一个51岁的男性患有慢性咳和疲劳的病例报告.
诊断程序包括成像,支气管活检,免疫组织化学和肺活检.
实验室检测发现了单克隆IgM卡帕血型病变.

主要成果:

支气管活检显示有颗粒细胞质的囊细胞,通过免疫组织化学确认为CSH.
检测到的一种单克隆IgM kappa gammopathy.
随后的肺活检证实了小B细胞非霍奇金淋巴瘤的透.

结论:

在对肺病变的差异诊断中应考虑CSH,特别是当非典型时.
组织病理学和免疫组织化学对于诊断CSH和识别相关的血液恶性瘤至关重要.
这一案例强调了CSH和淋巴增殖性疾病之间的联系.

关键词:

在 IgM kappa 中,结晶储存的胞细胞形成.囊细胞病变的病变单克隆性牙病变是一种单克隆性牙病变.血细胞分泌不良症血细胞分泌不良症肺淋巴瘤肺淋巴瘤小型B细胞淋巴瘤

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