测量肠道微生物群作为结直肠癌查工具:潜力和挑战
Andrea Severino1,2,3, Stefano Andrea Marchitto1,2,3, Piergiorgio Bisegna1,2,3
1Department of Translational Medicine and Surgery, Università Cattolica del Sacro Cuore, Rome, Italy.
Expert review of gastroenterology & hepatology
|November 18, 2025
概括
新的微生物组生物标志物对结直肠癌 (CRC) 查有希望,可能会改善便免疫化学测试 (FIT). 需要进一步的研究来验证这些用于早期检测的非侵入性工具,并彻底改变CRC诊断.
科学领域:
- 在瘤学瘤学.
- 微生物组研究 微生物组研究
- 诊断生物标志物 诊断生物标志物
背景情况:
- 结肠直肠癌 (CRC) 是全球主要的健康问题,查计划对于减少发病率和死亡率至关重要.
- 目前的查方法,如便免疫化学测试 (FIT),在诊断准确性方面存在局限性,导致错过诊断和不必要的程序.
研究的目的:
- 探索基于微生物组的生物标志物的潜力,作为用于结直肠癌 (CRC) 查的新型非侵入性工具.
- 突出需要在临床环境中进一步研究和验证这些生物标志物.
主要方法:
- 审查最近的元基因组元分析,确定与CRC相关的微生物特征.
- 讨论这些发现对当前和未来CRC查指南的影响.
主要成果:
- 已经确定了常见的微生物特征,可以区分CRC患者和健康个体.
- 国际指导方针现在建议在CRC查中探索微生物组生物标志物.
结论:
- 基于微生物组的生物标志物为通过早期,非侵入性检测彻底改变结肠直肠癌 (CRC) 查提供了一个有希望的途径.
- 多学科的努力和先进的计算方法对于确定可复制的签名以临床应用至关重要.
相关概念视频
Serum Laboratory Studies, Stool Test, Breath Test
735
Gastrointestinal (GI) diagnostic studies are pivotal in confirming, ruling out, diagnosing, or staging various diseases, including cancers. Following diagnosis, allocating time for discussions with the patient and providing informational resources is crucial. Diagnostic assessments of the GI tract often occur in outpatient settings like endoscopy suites or GI labs. Preparation for these tests may include dietary restrictions, fasting, liquid bowel preparations, laxatives, enemas, and the...
735
Assessment of the Rectum and Anus
1.1K
Evaluating the rectum and anus plays a crucial role in conducting a thorough physical examination of the gastrointestinal system. Although it may be uncomfortable and often embarrassing for the patient, it holds immense diagnostic value, particularly in detecting gastrointestinal diseases and abnormalities. This guide will explain how to perform this assessment using inspection and palpation methods.
Rectal Inspection
Begin by inspecting the perianal and anal areas for color, texture, rashes,...
Rectal Inspection
Begin by inspecting the perianal and anal areas for color, texture, rashes,...
1.1K
Imaging Studies III: Gastrointestinal Motility Studies and Virtual Colonoscopy
356
This lesson explores three gastrointestinal imaging techniques: radionuclide testing, colonic transit studies, and virtual colonoscopy.
Radionuclide Testing
Radionuclide testing is a sophisticated medical technique for assessing gastrointestinal motility. It focuses on gastric emptying and colonic transit time. Radioactive markers track the movement of food through the digestive system, providing insights into gastrointestinal disorders.
In gastric emptying studies, a meal's liquid and...
Radionuclide Testing
Radionuclide testing is a sophisticated medical technique for assessing gastrointestinal motility. It focuses on gastric emptying and colonic transit time. Radioactive markers track the movement of food through the digestive system, providing insights into gastrointestinal disorders.
In gastric emptying studies, a meal's liquid and...
356


