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Updated: Jun 25, 2026

Vasodilation of Isolated Vessels and the Isolation of the Extracellular Matrix of Tight-skin Mice
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开发和表征一种非共价刺激剂的干扰素基因蛋白质溶解向金马的开发和表征

Bo Hu1, Adam S Duerfeldt1

  • 1Department of Medicinal Chemistry, College of Pharmacy, University of Minnesota, Minneapolis, MN, 55455, USA.

ChemMedChem
|November 18, 2025
PubMed
概括

研究人员开发了新的蛋白质分解向嵌合体 (PROTACs) 来降解STING蛋白,这是先天免疫反应的关键调节者. 这种方法有效地抑制与过度激活的循环GMP-AMP合成酶 (cGAS) -STING信号传递相关的炎症.

关键词:
循环的GMP-AMP合成酶.这是一种炎症炎症炎症炎症.蛋白质降解 蛋白质降解蛋白质溶解的目标是嵌合体.干扰素基因的刺激剂.结构活动关系结构活动关系

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