非酒精性脂肪性肝病与乙型肝炎之间的关系:改善还是恶化? 一个系统的审查
1Gastroenterologist/Hepatologist, Department of Internal Medicine, Rivers State University Teaching Hospital, Port Harcourt, Rivers State.
West African journal of medicine
|November 18, 2025
概括
乙型肝炎病毒感染和非酒精性脂肪性肝病 (NAFLD) 有着复杂的关系. 主体代谢因素显著增加了慢性乙型肝炎患者的NAFLD的风险.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 病毒学 病毒学
- 代谢疾病 代谢疾病
背景情况:
- 尽管接种了疫苗,慢性乙型肝炎 (HBV) 仍然是一个全球性的健康问题.
- 肝炎病毒感染和非酒精性脂肪性肝病 (NAFLD) 之间的相互作用尚不清楚.
研究的目的:
- 系统地审查有关HBV感染和NAFLD之间的关系的现有文献.
- 为了确定与这种相互关系相关的风险因素.
主要方法:
- 2010-2021年间发表的英语语言研究的系统审查.
- 在包括PubMed,Scopus和Google Scholar在内的主要数据库中进行搜索.
- 使用PICO标准选择的研究,并使用纽卡斯尔-太华尺度进行评估.
主要成果:
- 包括11项涉及128,566个对照和5177个病例的研究.
- 乙型肝炎病毒和NAFLD之间的关系各不相同,发现了加重,改善和不存在的联系.
- 在HBV患者中,NAFLD的主要危险因素包括代谢因素 (肥胖,高血糖,失脂症,代谢综合征,高尿血症) 和HBx蛋白的存在.
结论:
- 在HBV患者中,NAFLD的发展与宿主代谢因素密切相关.
- 代谢健康是管理HBV患者的关键考虑因素.
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