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维生素C减弱了低水平的PM_2.5暴露引起的肺炎和线粒体损失

Xu Bai¹, Min Feng¹, Richard Y Kim¹

¹School of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, NSW 2007, Australia; Respiratory Cellular and Molecular Biology, Woolcock Institute of Medical Research, Macquarie University, Sydney, NSW 2113, Australia.

Environment international

|November 18, 2025

概括

低水平接触细颗粒物 (PM2.5) 通过增加氧化应激和炎症,损害肺部完整性. 在小鼠和人类细胞模型中,维生素C (VC) 补充有效地保护肺细胞免受这些有害影响.

科学领域:

环境健康环境健康
肺部毒理学肺部毒理学
氧化压力研究研究氧化压力研究

背景情况:

颗粒物 (PM2.5) 是已知的慢性肺部疾病的风险因素,特别是在高度污染的地区.
在欧洲和北美常见的低水平PM2.5暴露的不良影响往往被低估.
对于PM2.5暴露没有普遍安全的值,强调需要了解其在较低度的影响.

研究的目的:

为了研究低水平细颗粒物 (PM2.5) 暴露对肺部完整性的影响.
为了确定维生素C (VC) 对PM2.5引起的肺损伤的保护作用.
阐明PM2.5诱导的肺损伤背后的机制,重点关注氧化应激和线粒体功能障碍.

主要方法:

雄性Balb/c小鼠通过鼻腔暴露在低水平的PM2.5 (5μg/ml) 中,有或没有维生素C (VC) 补充.
在体外研究中使用了暴露于PM2.5并先用VC预处理的人类支气管上皮细胞 (BEAS-2B).
评估了反应性氧物种 (ROS),线粒体ROS,炎症标志物和细胞活性的水平.

主要成果:

暴露于PM2.5显著增加了小鼠的总ROS,线粒体ROS和炎症.
在体外,PM2.5降低了上皮细胞活力,增加了对氧化应激和炎症的敏感性.
在体内和体外模型中,补充维生素C有效抵消PM2.5引起的ROS,炎症和线粒体损伤的增加.

结论:

每日暴露于低水平的PM2.5通过诱导炎症和氧化应激介导的线粒体损伤,对肺部健康产生不利影响.
维生素C显示出显著的保护潜力,防止低水平PM2.5暴露对肺组织的有害影响.
这些发现强调了解决PM2.5即使是低度的呼吸系统健康的重要性,并建议VC作为潜在的预防剂.

关键词:

抗氧化剂是一种抗氧化剂.在BALF中,我们可以看到.贝斯-2B 贝斯-2B 是一个氧化应激是一种氧化应激.这就是ROSOS ROS.

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