周产期母体暴露会通过线粒体功能障碍和甲状腺功能干扰的介导诱导代际神经毒性
Lin Zhang1, An-Xin Lu2, Ling Li3
1Deprtment of Labor Health and Environmental Hygiene, School of Public Health, Lanzhou University, Lanzhou 730000, China; Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China.
Journal of hazardous materials
|November 18, 2025
概括
孕产妇接触,特别是来自骨储物中的,会伤害儿童.
科学领域:
- 环境健康 环境健康
- 神经毒理学 神经毒理学
- 内分泌学 在内分泌学.
背景情况:
- 周产期母亲 (Pb) 暴露是儿童早期Pb暴露的重要来源.
- 怀孕期间内生骨Pb调动是这种暴露的关键因素.
- 暴露与神经发育缺陷和甲状腺功能障碍有关.
研究的目的:
- 研究母亲骨Pb调动对后代神经发育的代际影响.
- 探索甲状腺-状细胞线粒体轴在Pb诱导的神经毒性的作用.
- 检查Pb暴露对神经发育和甲状腺功能影响的性别特异性差异.
主要方法:
- 使用一种老鼠模型对母体骨Pb动员进行研究.
- 评估后代的神经毒性,天体细胞线粒体损伤和母子甲状腺功能.
- 进行调解分析以确定母体甲状腺激素 (THs) 的作用.
- 在人类队列 (298对母婴对) 中分析了带血中的Pb水平,THs和婴儿运动技能.
主要成果:
- 母亲暴露Pb诱导后代的神经毒性,天体细胞线粒体损伤和母子甲状腺功能障碍.
- 母亲THs调解Pb诱导的代际神经毒性.
- 在人类中,带血Pb与女孩的精细运动得分相关,并在婴儿中破坏了TH水平 (特别是男孩的TT4).
- TSH和FT4水平与婴儿运动领域有负相关性,特别是在男孩中.
结论:
- "甲状腺-状细胞线粒体轴"是从产前母亲Pb暴露中产生代际神经毒性的关键途径.
- 内生Pb调动对神经发育结果构成重大风险.
- 研究结果显示,Pb神经毒性和甲状腺功能障碍的性别差异显著.
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