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在RAW 264.7细胞中,CYP450激活和线粒细胞诱导通过Ti₃C₂MXene排毒

Yujiao Liu¹, Xuan Mao², Yongyi Wei²

¹Department of Occupational and Environmental Health, School of Public Health, Tianjin Medical University, Tianjin 300070, China; Institute of Environmental Research at the Greater Bay Area, Key Laboratory for Water Quality and Conservation of the Pearl River Delta, Ministry of Education, Guangzhou University, Guangzhou 510006, China.

Journal of hazardous materials

|November 18, 2025

概括

巨细胞使用双重防御策略来排毒MXenes,二维纳米材料. 加快的氧化和线粒处理这些材料,揭示了设计更安全的纳米材料的新途径.

科学领域:

纳米技术和材料科学材料科学
细胞生物学和毒理学

背景情况:

工程纳米粒子,包括MXenes,存在环境和健康问题.
传统的毒理学往往忽视了细胞对纳米颗粒的防御机制.
MXenes是具有导电性和生物相容性的2D材料,但容易氧化.

研究的目的:

为了阐明MXenes的巨细胞排毒策略.
调查氧化降解在MXene加工中的作用.
探索MXene暴露激活的细胞防御机制.

主要方法:

使用了RAW 264.7巨细胞系.
研究了Ti3C2 MXene的细胞内氧化.
分析了CYP450酶,活性氧物种和线粒细胞衰变 (PINK1/帕金依赖) 的作用.

主要成果:

Ti3C2 MXene经历了加速的细胞内氧化,促进了解毒.
由MXene诱导的CYP450激活和ROS生成会将MXene代谢成少毒的氧化形式.
氧化损伤触发了PINK1/帕金因依赖的线粒,以去除受损的细胞器.

结论:

巨细胞对MXenes的排毒涉及一个双重的机制:氧化和线性.
氧化MXene是一种关键的排毒触发器,而不仅仅是物质限制.
这些发现为设计更安全的二维纳米材料提供了一个新的范式,需要对长期影响进行未来的研究.

关键词:

通过 CYP450 的氧化.细胞的排毒细胞的排毒.环境可持续性环境可持续性这就是MXene MXene.线粒细胞衰变 - - 线粒细胞衰变 (mitophagy) 是一种

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