抗骨吸收疗法的度和骨矿物质密度变化之间的关系
Akira Horikawa1, Yuji Kasukawa2, Michio Hongo2
1Shizuoka Tokusyukai Hospital, 1-11 Surugaku-Simokawahara-Minami, Shizuoka 421-0117, Japan.
概括
骨质疏松症治疗后血清的早期下降预测了更好的骨矿物质密度增长. 这一发现表明,在接受佐列龙酸或denosumab的患者中,治疗反应的潜在生物标志物.
科学领域:
- 内分泌学 在内分泌学.
- 代谢性骨疾病 代谢性骨疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 低血症是骨质疏松症抗吸收疗法的已知并发症.
- 早期血清变化与长期骨矿物质密度 (BMD) 反应之间的关系尚不清楚.
研究的目的:
- 为了比较早期的血清校正的 (Ca) 变化和随后的骨质疏松症患者的骨质疏松症结局,这些患者接受了列龙酸治疗,而不是denosumab.
主要方法:
- 对67名骨质疏松症门诊患者 (25名索尔德龙酸,42名德诺苏马布) 的回顾性研究.
- 在基线和随访点 (1周至12个月) 监测血清校正的Ca,BMD,eGFR和骨周转率标志物.
- 多变量回归调整为年龄,基线BMD,25(OH) D,eGFR和TRACP-5b.
主要成果:
- 这两个治疗组在1周后显示血清校正的Ca显著下降.
- 在这两组中,这种早期Ca减少的幅度与12个月后的腰椎骨质量变化有负相关性.
- 接收器操作特征 (ROC) 分析表明,较大的Ca减少预测了更高的BMD增长,尽管由于样本大小和多种维生素D疗法,结果需要谨慎解释.
结论:
- 抗吸收药物治疗后血清校正的早期减少与12个月后改善的BMD增长相关.
- 这种关联独立于基线维生素D,功能和骨周转标志物.
- 这些发现是初步的,需要在更大,标准化的研究中进行进一步调查.
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