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长期COVID肺 perfusion 和通风缺陷的纵向评估:使用阶段解决的功能性肺 (PREFUL) MRI进行为期一年的研究

Tao Ouyang¹, Zhenghui Huang², Shuxing Wei²

¹Department of Radiology, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, 1 Banshan East Rd, Hangzhou 310022, China; Department of Radiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, 100020, China; Key Lab. of Medical Engineering for Cardiovascular Disease, Ministry of Education, Beijing, 100020, China; Laboratory for Clinical Medicine, Capital Medical University, Beijing, 100020, China.

Computers in biology and medicine

|November 18, 2025

概括

在SARS-CoV-2感染后,肺 perfusion 缺陷持续长达12个月. 严重的急性阶段输液障碍是患长期COVID的危险因素.

科学领域:

肺部成像和呼吸系统医学

背景情况:

在SARS-CoV-2感染后的长期肺部变化尚不清楚.
评估肺 perfusion 和通风缺陷对于了解COVID-19后呼吸系统后果至关重要.

研究的目的:

在SARS-CoV-2感染后的患者中使用相位解决的功能性肺部 (PREFUL) MRI 纵向评估肺 perfusion (QDP) 和通风 (VDP) 缺陷.
为了确定长期COVID的发展风险因素.

主要方法:

包括COVID-19患者和健康对照在内的前性研究.
在症状出现后的急性,3,6和12个月进行连续的PREFULMRI扫描.
线性混合效应模型用于纵向比较;长期COVID风险因素的后勤回归.

主要成果:

肺透气缺陷 (VDP_联合) 在12个月内显著改善,接近健康的对照水平.
肺 perfusion 缺陷 (QDP) 显著下降,但与12个月的对照组相比仍然很高.
较高的急性期QDP与患长期COVID的风险增加有关 (OR,1.20;P = 0.001).

结论:

肺 perfusion 障碍持续在SARS-CoV-2感染后的 12 个月内.
严重的急性阶段输液缺陷是长期COVID发展的重要危险因素.

关键词:

长时间的COVID.输液缺陷的百分比是多少阶段解决的功能性肺部.通风系统缺陷的百分比是多少

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