酸盐增强了肠道Parasutterella的殖民,以减轻辐射伤害
Yuan Li1, Jiwei Qiu1, Zhihong Liu2
1Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China.
Cell chemical biology
|November 18, 2025
概括
在植物性饮食中发现的花酸盐通过恢复器官健康和改善肠道完整性来减轻放射治疗并发症. 这表明,植物酸盐及其衍生代谢物可以帮助接受放射治疗的癌症患者.
科学领域:
- 营养科学 营养科学
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
背景情况:
- 食品作为药物是一个日益增长的疾病干预领域.
- 植物性饮食中丰富的花酸盐,因其治疗潜力而受到探索.
- 放射治疗往往会引起显著的副作用,包括器官损伤和炎症.
研究的目的:
- 研究植物酸盐在缓解放射治疗引起的并发症方面的疗效.
- 阐明植物酸盐保护作用背后的机制.
- 为了确定潜在的微生物和代谢对植物酸盐作用的贡献者.
主要方法:
- 在被辐射的小鼠中,用口腔测量酸盐.
- 评估血源性器官的健康状况,周围血液细胞计数,炎症标志物和胃肠道完整性.
- 用体外和非向代谢学分析肠道微生物群和识别关键代谢物.
- 在体外,体外和体内测试以确定已识别的代谢物的功能.
主要成果:
- 植物酸盐的使用恢复了血液性器官缩,增加了中性粒细胞和白细胞,减少了炎症,改善了胃肠道完整性.
- 酸盐调节了肠道微生物群,促进了共生细菌Parasutterella.
- 帕拉苏特雷拉产生的3-乳酸 (PLA) 和N-乙-L-氨酸 (NL),通过诱导M2类巨细胞两极分化和减少氧化应激,分别抵消辐射毒性.
结论:
- 酸盐有效地缓解了小鼠的放射治疗相关并发症.
- 肠道细菌Parasutterella及其代谢物,PLA和NL,在植物酸盐的保护作用中起着关键作用.
- 帕拉苏特雷拉及其代谢产物在接受放射治疗的癌症患者中显示出作为益生菌或后生菌的前景.
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