[一个尿的病例呈现为氧化诱导的急性外周神经病变]
Yoshinori Noguchi1, Takuji Shibahara, Tomohiro Miyake
1Dept. of Pharmacy, Japanese Red Cross Ise Hospital.
Gan to kagaku ryoho. Cancer & chemotherapy
|November 18, 2025
概括
奥克萨利普拉丁 (L-OHP) 可以引起尿,这是一种可能因良性前列腺增生而加剧的副作用. 这种风险因素应考虑在接受晚期结肠癌化疗的患者.
科学领域:
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
背景情况:
- 患有西格结肠癌和肝转移病史的患者,接受多种化疗方案治疗.
- 进展性疾病和淋巴结转移导致治疗修改.
- 之前的治疗包括FOLFOX4+贝瓦齐祖马布 (BEV),泰加/乌拉和泰加/吉梅拉/奥特拉.
研究的目的:
- 报告与oxaliplatin (L-OHP) 管理相关的尿留病例,该病例发生在患有晚期结肠癌的患者中.
- 调查良性前列腺增生 (BPH) 在L-OHP诱导的尿中的潜在贡献作用.
主要方法:
- 病例报告详细介绍了患者对西格状结肠癌的治疗史.
- 在CAPOX+BEV化疗期间观察尿液保留,特别是在L-OHP给药期间.
- 在切换到CAPIRI+BEV后,停止L-OHP和随后的尿症状的消失.
主要成果:
- 在CAPOX+BEV化疗的背景下,L-OHP的使用期间发生了尿留.
- 症状在停止使用L-OHP时消失.
- 这名患者在5年前被诊断出先前存在的良性前列腺增生症 (BPH).
结论:
- 氧化 (L-OHP) 诱导的急性周围神经病变是尿的可能原因.
- 良性前列腺增生 (BPH) 可能是一个显著的危险因素,加剧L-OHP诱导的尿.
- 这一案例凸显了在管理化疗副作用时考虑BPH等先前存在的疾病的重要性.
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