在变化的重力引起的抛物线飞行过程中,promethazine对运动疾病的影响
Aerospace medicine and human performance
|November 18, 2025
概括
在模拟零重力 (0-G) 和部分重力的抛物线飞行期间,Promethazine有效地减少了宇航员的太空运动恶心. 与安慰剂相比,这种药物显著降低了症状,提高了宇航员的安全性和性能.
科学领域:
- 太空医学 太空医学
- 航空航天生理学
- 航空中的人类因素
背景情况:
- 太空运动病是宇航员的常见问题,影响了性能和安全.
- 现有的制药对抗太空运动病的措施缺乏在偏重环境中进行广泛的研究.
研究的目的:
- 调查口服普罗梅塔在减轻太空行驶病的疗效.
- 评估普罗马素在抛物线飞行期间对运动恶心症状的影响,模拟零重力 (0-G) 和部分重力.
主要方法:
- 12名受试者进行了抛物线飞行,每人使用10个抛物线在0g,0.25g,0.50g和0.75g的速度.
- 参与者接受了25毫克口服普罗马或安慰剂,在平衡设计中.
- 用Pensacola运动病问卷量化运动病,在飞行前,飞行后和飞行期间收集得分.
主要成果:
- 据报道,安慰剂组在0-G中与飞行前相比,在飞行后的运动病得分显著更高.
- 普罗米他辛减少了报告的运动恶性病例,从安慰剂组中的51.8%的抛物线减少到普罗米他辛组的12.6%.
- 接受普罗梅素治疗的6名受试者中,有4人没有报告运动恶心,而所有安慰剂受试者都出现了症状.
结论:
- 口服普罗梅塔辛在零-G和部分重力条件下有效降低太空运动病症状.
- 零重力 (0-G) 可能会引起比部分重力更严重的运动恶心,可能是由于更大的感官冲突.
- 建议进行进一步的研究,以探索不同低重力水平的运动性疾病.
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