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Updated: Jan 11, 2026

Generation of Human Nasal Epithelial Cell Spheroids for Individualized Cystic Fibrosis Transmembrane Conductance Regulator Study
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Published on: April 11, 2018

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CFTR调制剂疗法通过改善囊性纤维化宿主生理学推动微生物组重组:IMMProveCF第四阶段试验

Rebecca Luise Knoll1,2,3,4,5, Melanie Meihua Brauny6,7,8, Evelyn Robert1

  • 1Children's Hospital, University Medical Center of the Johannes Gutenberg‑University Mainz, Mainz, Germany.

Nature communications
|November 18, 2025
PubMed
概括

囊性纤维化 (CF) 的elexacaftor/tezacaftor/ivacaftor (ETI) 治疗改善了CFTR功能,减少了唾液中的葡萄球菌. 肠道微生物组的变化,包括降低埃舍里希亚菌,也发生,表明ETI部分逆转CF相关的失生症.

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