无动于衷的自我意识及其神经关联在帕金森病中
Hannah Conn1, Hideo Suzuki1, Zekai Jin2
1Department of Neurology, Baylor College of Medicine, Houston, TX, USA.
NPJ Parkinson's disease
|November 18, 2025
概括
帕金森病的冷漠影响生活质量. 患者对冷漠的自我意识受损 (ISA-a) 与大脑连接的改变有关,特别是在情感领域.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 精神病学是一个精神病学.
背景情况:
- 漠不关心是帕金森病 (PD) 的常见非运动症状,显著降低患者的生活质量.
- 丧失对冷漠的自我意识 (ISA-a) 进一步使患者管理复杂化,因为它阻碍了对护理的参与.
- 之前的研究将PD中的冷漠与前-上功能连接 (FC) 的减少联系起来,但ISA-a的神经基础尚不清楚.
研究的目的:
- 在帕金森病 (PD) 中调查无动于衷的自我意识受损 (ISA-a).
- 探索ISA-a的神经基础,使用对冷漠 (启动,执行,情绪) 的维度方法.
- 检查与无动于衷和ISA-a相关的功能连接 (FC) 改变在PD.
主要方法:
- 休息状态功能磁共振成像 (fMRI) 在3T扫描仪上使用.
- 该研究包括52名患有PD的ISA-a评估人员和35名患有PD的神经基础调查人员.
- 应用了一个维度方法来分析冷漠 (启动,执行,情绪) 和它的自我意识.
主要成果:
- 42%的无动于衷的PD患者表现出较差的自我意识与非无动于衷的个人相比.
- 在无动于衷的PD患者中观察到左前环状皮层 (ACC) 与左侧核 (NAcc) 之间的功能连接性 (FC) 减少的趋势.
- 在ISA-a中的趋势,特别是在情绪领域,与左NAcc和轨道前皮层之间改变的FC,以及右ACC和右前岛皮层之间的FC有关.
结论:
- 研究结果表明,潜在的神经机制有助于帕金森病中的冷漠和ISA-a.
- 特定大脑区域的功能连接的改变可能是对这种症状的冷漠和缺乏自我意识的基础.
- 需要对较大群体进行进一步的研究,以证实这些神经相关性,并为治疗策略提供信息.
更多相关视频
07:26Characterizing the Relationship Between Eye Movement Parameters and Cognitive Functions in Non-demented Parkinson's Disease Patients with Eye Tracking
Published on: September 26, 2019
8.2K
07:42An Automated T-maze Based Apparatus and Protocol for Analyzing Delay- and Effort-based Decision Making in Free Moving Rodents
Published on: August 2, 2018
14.3K
相关概念视频
Parkinson's Disease: Overview
1.7K
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
1.7K
Neural Regulation
43.0K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
43.0K
Parkinson's Disease: Treatment
953
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
953
Self-Awareness and Its Effects
263
Self-awareness is a psychological state in which the individual becomes the focal point of their attention. This inward focus transforms the self into an object of contemplation and assessment, influencing how individuals perceive their actions and their alignment with personal and societal standards.Triggers and Contexts for Self-AwarenessSelf-awareness can be activated by external stimuli that make individuals visually or audibly aware of themselves, such as mirrors, cameras, or recordings.
263
Negative and Cognitive Symptoms of Schizophrenia
416
Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
416
Alzheimer's Disease: Overview
1.6K
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
1.6K
