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Updated: Jan 11, 2026

Crystal Structure of the N-terminal Domain of Ryanodine Receptor from Plutella xylostella
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瑞亚诺丁受体的晶体结构揭示了丹特烯和阿祖烯相互作用,指导了抑制剂的发展

Hadiatullah Hadiatullah1, Lianyun Lin1, Zhiyan Wang2

  • 1State Key Laboratory of Synthetic Biology; Frontiers Science Center for Synthetic Biology; Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency; School of Pharmaceutical Science and Technology, Faculty of Medicine, Tianjin University, Tianjin, China.

Nature communications
|November 18, 2025
PubMed
概括

研究人员确定了与抑制剂结合的瑞诺丁受体 (RyR) Repeat12域的晶体结构. 这揭示了dantrolene和类似物如何结合,指导开发更安全,更有效的RyR抑制剂.

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