孕激素原始卵巢刺激的结果与控制卵巢过度刺激的GnRH抗剂协议的结果相似
Elif Meseci1, Sabri Berkem Okten1, Sevgi Bilgen2,3
1Department of Obstetrics and Gynecology, IVF Department, Acıbadem Kozyatagı Hospital, Istanbul, Turkey.
Scientific reports
|November 18, 2025
概括
孕激素主导的卵巢刺激 (PPOS) 协议与辅助生殖技术周期的淋巴激素释放激素 (GnRH) 反对者协议同样有效. 这两种方法在卵细胞产量,胚胎质量和怀孕率方面都显示出相似的结果.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 辅助生殖技术 (ART) 是一种辅助生殖技术.
背景情况:
- 在ART循环中预防黄素激素的激增通常涉及GnRH类似物或孕激素.
- 有限的数据直接比较了这两种策略的有效性和可靠性.
研究的目的:
- 在ICSI周期中,比较孕激素原制卵巢刺激 (PPOS) 和GnRH对抗剂协议之间的卵巢刺激结果.
- 评估PPOS与GNRH抗剂协议之间的可靠性和有效性.
主要方法:
- 对385个ICSI周期 (2022年1月 - 2023年11月) 的回顾性研究.
- 150名患者接受了PPOS协议,235人接受了GnRH抗剂协议.
- 分析卵细胞产量,胚胎质量,受精和怀孕结果.
主要成果:
- 在PPOS和GnRH抗组之间没有观察到卵细胞产量,胚胎质量,受精率或怀孕结果的显著差异.
- 协议类型没有影响活产率 (LBR).
- 与较低的LBR相关的因素包括更长的不孕期和减少的卵巢储备;更高质量的胚胎和胚胎囊形成率改善了LBR.
结论:
- 在ICSI周期中,PPOS协议的疗效与GnRH抗剂协议在卵巢刺激方面具有可比性.
- PPOS是一种可行的和有效的替代方案,用于控制卵巢过度刺激.
- 未来的研究应该专注于影响活产率的因素,而不仅仅是刺激协议.
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