确定在阳门手术中在白天手术期间用于脊髓麻醉的最佳罗皮瓦卡因度:剂量确定研究
Lu Chen1, Xujun Dong2, Jianhua Chen2
1Department of Anesthesiology, People's Hospital Of Xiushan County, Chongqing, China.
Scientific reports
|November 18, 2025
概括
这项研究确定了在直肠手术期间用于脊髓麻醉的罗皮瓦卡因最小有效度. 0.2482%的度在90%的患者中是有效的,为99%的疗效建议0.2926%.
科学领域:
- 麻醉学 麻醉学
- 药理学 药理学是指药理学的学科.
背景情况:
- 罗皮瓦卡因是一种广泛使用的局部麻醉剂,用于脊髓麻醉 (SA).
- 选择性直肠手术的最佳罗皮瓦卡因度需要精确的估计.
- 脊柱麻醉对于在门手术过程中有效的疼痛管理至关重要.
研究的目的:
- 确定罗皮瓦卡因的最低有效度 (MEC90) 以在接受选择性直肠手术的患者中成功进行脊髓麻醉.
- 在这个患者群体中确定罗皮瓦卡因的MEC99.
- 为罗皮瓦卡因诱导的脊髓麻醉提供基于证据的度指导方针.
主要方法:
- 采用了一个有偏见的硬币设计和上下移动的方法.
- 51名年龄在18-65岁之间的患者接受了脊髓麻醉,用1.5毫升的罗皮瓦卡因化.
- 度从0.30%开始,并以0.05%的增量进行调整.
主要成果:
- 罗皮瓦卡因用于脊髓麻醉的MEC90发现为0.2482% (3.7320毫克).
- 在1.5毫升中,MEC99被推断为0.2926% (4.4389毫克).
- 对于MEC90的置信区间为0.1500-0.3000%,对于MEC99的置信区间为0.2500-0.3000%.
结论:
- 在接受直肠手术的90%患者中,0.2482% (3.7320毫克) 的罗皮瓦卡因度对脊髓麻醉有效.
- 建议度为0.2926% (4.4389毫克),以达到99%的疗效.
- 这些发现为优化在门手术中脊髓麻醉中罗皮瓦卡因剂量的优化提供了关键数据.
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