多发性硬化症干预中较少跌倒的可行性和结果:一个试点随机对照试验
Ulrika Meijer1, Charlotte Ytterberg2,3, Kristina Gottberg2
1Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Huddinge, Sweden. ulrika.meijer@ki.se.
Scientific reports
|November 18, 2025
概括
这项试点研究发现,在线计划"减少MS的发生"对于患有多发性硬化症 (MS) 的人来说是可行的. 虽然没有观察到明显的下降减少,但干预措施.
科学领域:
- 神经学 神经学
- 康复科学 康复科学 康复科学
- 公共卫生 公共卫生
背景情况:
- 对于患有多发性硬化症 (PwMS) 的人来说,跌倒是一个重大问题,影响受伤风险和生活质量.
- 在PwMS中跌倒的复杂性要求量身定制,全面的预防策略.
- 现有的干预措施可能无法充分满足门诊和非门诊PwMS的需求.
研究的目的:
- 评估"在MS中减少落"在线自主管理落预防计划的可行性和结果.
- 确定干预是否有必要进行全面的随机对照试验 (RCT).
主要方法:
- 一项试点随机对照试验,涉及瑞典各地的46名PwMS.
- 参与者被分配到"较少发生MS"干预组 (n=23) 或对照组 (n=23).
- 该干预包括每周一次在线小组会议和一次强化学习,在18周内通过短信监测跌倒情况.
主要成果:
- 该试点在招聘,保留,数据收集,干预交付和遵守方面证明了可行性.
- 在18周后,干预组和对照组之间没有发现下降率或结果的显著差异.
- 在研究期间没有报告任何不良事件.
结论:
- "较少发生多发性硬化症"的干预措施对PwMS来说是可行的和安全的.
- 虽然在这个试点中没有统计学意义,但该计划的可行性支持向全面的RCT进步.
- 基于试验结果的改进将加强未来试验的干预和结果措施.
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