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Updated: Jan 11, 2026

Assessment of Human Natural Killer Cell Events Driven by FcγRIIIa Engagement in the Presence of Therapeutic Antibodies
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通过IRE1α-XBP1s-STAT3-UBE2S轴对NSCLC中IL-6介导的NK细胞功能障碍的机制性见解

Yazhen Wang1, Zichan Guo2, Anqi Xu1,3

  • 1Department of Immunology, Fourth Military Medical University, Xi'an, Shaanxi, China.

NPJ precision oncology
|November 18, 2025
PubMed
概括

自然杀手 (NK) 细胞免疫疗法在非小细胞肺癌 (NSCLC) 中效率较低,因为瘤抑制NK细胞. 这项研究揭示了一种涉及XBP1s,IL-6和UBE2S的机制,该机制减少NKp30,损害NSCLC中的NK细胞功能.

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