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重复植入失败的花细胞殖民地刺激因子:为期5年的队列研究结果

Islam Elkhateb¹, Radwa Fahmy², Wafaa Ramadan²

¹Department of Obstetrics and Gynaecology, Students' Hospital, Cairo University, Cairo, Egypt. islam.t.elkhateb@residents.kasralainy.edu.eg.

Scientific reports

|November 18, 2025

概括

颗粒细胞殖民地刺激因子 (G-CSF) 的子宫内输注显著改善了复发性植入失败 (RIF) 患者的植入率. 虽然没有统计学意义,但G-CSF在RIF管理中显示出对怀孕和堕胎率的潜在益处.

科学领域:

生殖医学生殖医学
不孕症研究不孕症研究
临床胚胎学临床胚胎学

背景情况:

复发性植入失败 (RIF) 在辅助生殖技术中构成了重大挑战,对患者产生经济和心理影响.
颗粒细胞殖民地刺激因子 (G-CSF) 正在研究其提高RIF患者胚胎植入和怀孕率的潜力.

研究的目的:

评估G-CSF的子宫内输注 (IU) 在改善新鲜胚胎移植 (ET) 经历RIF的患者的怀孕和植入结果方面的疗效.

主要方法:

一项涉及RIF患者接受新鲜ET的宏观观察队列研究.
患者在卵细胞检索后和新鲜ET之前接受了IU G-CSF输液;对照组在G-CSF实施之前接受了标准护理.
排除标准包括先进的母亲年龄 (>42岁) 和影响植入的显著子宫,免疫或遗传因素.

主要成果:

与对照组 (n=39) 相比,研究组 (n=40) 的植入率显著更高 (0.33±0.25对比0.33±0.08,P=0.04).
临床怀孕率 (27.5%对17.9%) 和化学怀孕率 (35%对23%) 在研究小组中较高,尽管在统计学上并不显著.
在G-CSF组中,第一季度堕胎率较低 (18.2%对42.9%),但这种差异在统计学上并不显著.

结论:

在新鲜的ET之前,在异常RIF患者的子宫内G-CSF给药显著改善了植入率.
在这个队列中,G-CSF没有显著改变临床或化学妊娠率或第一季度堕胎率.
可能需要进一步的研究来探索G-CSF在优化RIF管理中的作用.

关键词:

辅助生殖技术是一种辅助生殖技术.胚胎植入胚胎的植入方式菲尔格拉斯蒂姆可以使用.颗粒细胞殖民地刺激因子怀孕率怀孕率怀孕率

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