Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

14.6K
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
14.6K
T Cell Types and Functions01:24

T Cell Types and Functions

2.1K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
2.1K
Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

8.4K
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
8.4K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Sequential infection reprograms the immune landscape to shape future responses.

bioRxiv : the preprint server for biology·2026
Same author

Mechanosensing by T cells promotes a tissue-resident memory transcriptional program.

Nature immunology·2026
Same author

Pregnancy-induced tissue-resident memory-like T cells contribute to tumor control in breast cancer.

Nature immunology·2026
Same author

New insights into progenitor exhausted T cell populations.

Nature reviews. Immunology·2026
Same author

Type I interferons enhance B cell activation and promote differentiation of double negative 2 cells in SLE.

Lupus science & medicine·2026
Same author

IL-2 mutein promotes antigen-specific transplant acceptance in mice through expansion of ST2<sup>+</sup> regulatory T cells.

Nature communications·2026

相关实验视频

Updated: Jan 11, 2026

Generating De Novo Antigen-specific Human T Cell Receptors by Retroviral Transduction of Centric Hemichain
08:48

Generating De Novo Antigen-specific Human T Cell Receptors by Retroviral Transduction of Centric Hemichain

Published on: October 25, 2016

9.0K

关于T细胞命名的指导方针

David Masopust1, Amit Awasthi2, Rémy Bosselut3

  • 1Department of Microbiology & Immunology, Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA. masopust@umn.edu.

Nature reviews. Immunology
|November 18, 2025
PubMed
概括

由于T细胞的异质性,需要新的命名法. 这份共识声明提出了标准化定义和模块化命名法,以提高T细胞研究沟通的清晰度.

更多相关视频

Mouse Na&#239;ve CD4+ T Cell Isolation and In vitro Differentiation into T Cell Subsets
07:12

Mouse Naïve CD4+ T Cell Isolation and In vitro Differentiation into T Cell Subsets

Published on: April 16, 2015

54.1K
Streamlined Single Cell TCR Isolation and Generation of Retroviral Vectors for In Vitro and In Vivo Expression of Human TCRs
11:21

Streamlined Single Cell TCR Isolation and Generation of Retroviral Vectors for In Vitro and In Vivo Expression of Human TCRs

Published on: September 10, 2017

10.0K

相关实验视频

Last Updated: Jan 11, 2026

Generating De Novo Antigen-specific Human T Cell Receptors by Retroviral Transduction of Centric Hemichain
08:48

Generating De Novo Antigen-specific Human T Cell Receptors by Retroviral Transduction of Centric Hemichain

Published on: October 25, 2016

9.0K
Mouse Na&#239;ve CD4+ T Cell Isolation and In vitro Differentiation into T Cell Subsets
07:12

Mouse Naïve CD4+ T Cell Isolation and In vitro Differentiation into T Cell Subsets

Published on: April 16, 2015

54.1K
Streamlined Single Cell TCR Isolation and Generation of Retroviral Vectors for In Vitro and In Vivo Expression of Human TCRs
11:21

Streamlined Single Cell TCR Isolation and Generation of Retroviral Vectors for In Vitro and In Vivo Expression of Human TCRs

Published on: September 10, 2017

10.0K

科学领域:

  • 免疫学 免疫学 免疫学
  • 细胞生物学 细胞生物学
  • 遗传学 是一个遗传学.

背景情况:

  • 人们越来越认识到T细胞的异质性.
  • 现有的T细胞命名法不足以描述这种多样性.
  • 这导致了不一致的定义和沟通挑战.

研究的目的:

  • 建议T细胞子集指标的指导方针.
  • 为了标准化常用的T细胞子集的定义.
  • 引入T细胞的新型"模块化命名法".

主要方法:

  • 使用基于共识的方法.
  • 审查现有的T细胞子集定义和文献.
  • 开发一个新的命名体系框架.

主要成果:

  • 建议在初级研究中定义T细胞子集的指导方针.
  • 提供了现有的T细胞子集的标准化定义.
  • 介绍了一个模块化命名系统,重点关注单个生物特性.

结论:

  • 拟议的指导方针提高了T细胞研究的透明度.
  • 标准化定义和模块化命名法改善了T细胞发现的沟通.
  • 这些进展使T细胞生物学领域的研究人员,学生和临床医生受益.