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Updated: Jan 11, 2026

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web
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Published on: July 16, 2017

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蛋白质的温度依赖结构组合的深度生成建模

Giacomo Janson1, Alexander Jussupow1, Michael Feig2

  • 1Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI, USA.

Communications chemistry
|November 18, 2025
PubMed
概括

像aSAM和aSAMt这样的深度学习模型现在可以通过从分子动力学模拟中学习以降低计算成本,从而产生准确的蛋白质构造组合,包括温度效应.

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Temperature Dependent Deformation01:12

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In a nonhomogeneous rod made up of steel and brass, restrained at both ends and subjected to a temperature change, several steps are involved in calculating the stress and compressive load. Due to the problem's static indeterminacy, one end support is disconnected, allowing the rod to experience the temperature change freely. Next, an unknown force is applied at the free end, triggering deformations in the rod's steel and brass portions. These deformations are then calculated and added...
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Protein domains are small structurally independent units that are part of a single amino acid chain.  Although these domains are often structurally independent, they may rely on synergistic effects to perform their functions as part of a larger protein. Protein domains may be conserved within the same organism, as well as across different organisms.
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