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Updated: Jan 11, 2026

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通过与EGFR和TLR信号通路的功能相互作用,PYCR1驱动肺癌的进展

Ji Hye Shin1, Ji Young Kim1, Mi-Jeong Kim2,3

  • 1Department of Immunology, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Suwon, Republic of Korea.

Experimental & molecular medicine
|November 18, 2025
PubMed
概括

皮洛林-5-碳酸盐还原酶1 (PYCR1) 通过稳定EGFR和促进TLR信号传递,驱动非小细胞肺癌 (NSCLC) 的进展. 用PYCR1-IN-1抑制PYCR1抑制了瘤生长,提供了一个潜在的NSCLC治疗策略.

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