生物衰老的葡萄糖状况依赖的蛋白质特征,用于健康风险预测
Jiang Li1, Jie Li1, Xiaoqin Xu1
1Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China.
GeroScience
|November 18, 2025
概括
这项研究揭示了基于血糖状况的独特蛋白质衰老模式,开发了蛋白质衰老得分 (ProAS),改善了对死亡率和疾病的健康风险预测,特别是在正常血糖水平的个体中.
科学领域:
- 生物标志物和衰老研究.
- 蛋白质组学和代谢健康
- 个性化的风险预测和预测.
背景情况:
- 目前的蛋白质衰老时钟缺乏针对血糖状况的个性化.
- 血糖状况显著影响衰老轨迹和健康风险.
- 需要量身定制的衰老生物标志物和风险评估工具.
研究的目的:
- 为了识别衰老的葡萄糖状况依赖的蛋白质基因特征.
- 开发蛋白质衰老评分 (ProAS) 以提高健康风险预测.
- 调查ProAS与不同血糖组的死亡率和发病率的关联.
主要方法:
- 在46,047名英国生物库参与者中测量了2923种血蛋白,使用Olink.
- 采用三步查来识别与死亡相关的蛋白质生物标志物.
- 开发了特定于血糖状况的蛋白质老化得分 (ProAS).
主要成果:
- 分别确定了11,23和21个蛋白质生物标志物,用于正常血糖,糖尿病前期和糖尿病中的死亡率.
- GDF15,EDA2R和WFDC2是常见的生物标志物;GDF15和WFDC2显示为特定组的重要性.
- ProAS改善了死亡率和疾病的预测,随着血糖状况恶化,性能下降.
结论:
- 蛋白质衰老模式是特定于血糖状况的,延长了当前的衰老时钟.
- 特定于血糖状况的ProAS为与年龄相关的结果提供了精细的风险分层.
- 这些发现支持基于个体血糖概况的健康衰老的有针对性的干预措施.
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