在慢性阻塞性肺病中对乳杆菌益生菌混合物的双盲随机安慰剂控制试验
Teodora Nicola1, Nancy M Wenger1, Kara Seidman1
1Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL, USA.
一种益生菌和草药混合物 (resB®),每天服用,改善了慢性阻塞性肺病 (COPD) 患者的呼吸系统症状和减少炎症. 这表明通过调节肠道和肺部细菌,对肺部健康有潜在的益处.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 肺部病理学 肺部病理学
背景情况:
- 肠道微生物群影响全身免疫反应,影响肺部健康.
- 益生菌补充剂可以支持肺部健康.
- 慢性阻塞性肺病 (COPD) 影响生活质量.
研究的目的:
- 在COPD患者中评估益生菌混合与草本提取物 (resB®) 的安全性和有效性.
- 评估resB®对生活质量和呼吸系统症状的影响.
- 研究resB®对炎症生物标志物和微生物群组成的影响.
主要方法:
- 进行了一项随机,双盲,安慰剂对照试验 (NCT05523180).
- 参与者每天接受resB®或安慰剂囊,持续12周.
- 使用圣乔治呼吸道问卷 (SGRQ) 来测量生活质量;安全性,生物标志物和微生物群也被评估.
主要成果:
- 与安慰剂相比,resB®显著改善了SGRQ症状得分.
- resB®补充剂导致MMP-9,CRP和IL-6的血清和唾液水平降低.
- 改善与增加的便相关联 肠道和肺部微生物群中的乳酸菌和Veillonella丰度增加.
结论:
- resB®在COPD患者中显示出改善呼吸道症状的潜力.
- 草药和益生菌混合物可以减少全身炎症.
- 肠道和肺部微生物群的调节似乎是一个关键的作用机制.
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