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相关概念视频

The DNA Helix01:16

The DNA Helix

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The DNA Helix01:07

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Deoxyribonucleic acid, or DNA, is the genetic material responsible for passing traits from generation to generation in all organisms and most viruses. DNA is composed of two strands of nucleotides that wind around each other to form a spring-like structure called a double helix. However, the double helix is not perfectly symmetrical. Instead, there are regularly occurring grooves in the structure. The major groove occurs where the sugar-phosphate backbones are relatively far apart. This space...
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Single-Strand DNA Binding Proteins01:03

Single-Strand DNA Binding Proteins

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For successful DNA replication, the unwinding of double-stranded DNA must be accompanied by stabilization and protection of the separated single strands of the DNA. This crucial task is performed by single-strand DNA-binding (SSB) proteins. They bind to the DNA in a sequence-independent manner, which means that the nitrogenous bases of the DNA need not be present in a specific order for binding of SSB proteins to it. The binding of SSB proteins straightens single-stranded DNA (ssDNA) and makes...
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Two structural features of the DNA molecule provide a basis for the mechanisms of heredity: the four nucleotide bases and its double-stranded nature. The Watson-Crick model of double-helical DNA structure, proposed in 1952, drew heavily upon the X-ray crystallography work of researchers Rosalind Franklin and Maurice Wilkins. Watson, Crick, and Wilkins jointly received the Nobel Prize in Physiology or Medicine for their work in 1962. Franklin was, controversially, excluded from the prize for...
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In order to be passed through generations, genomic DNA must be undamaged and error-free. However, every day, DNA in a cell undergoes several thousand to a million damaging events by natural causes and external factors. Ionizing radiation such as UV rays, free radicals produced during cellular respiration, and hydrolytic damage from metabolic reactions can alter the structure of DNA. Damages caused include single-base alteration, base dimerization, chain breaks, and cross-linkage.
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Agarose gel electrophoresis is a laboratory technique commonly used to separate DNA fragments by size. However, it can also be used to isolate and purify DNA fragments using a gel extraction protocol.
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开发用于控制DNA中电荷传输的设计指南.

Zahra Aminiranjbar1, Caglanaz Akin Gultakti2,3, Amy Zhang1

  • 1Department of Electrical and Computer Engineering, University of California Davis, Davis, CA, USA.

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概括

研究人员制定了设计指南,以控制DNA的电子结构. 操纵DNA序列可以改变电荷传输特性,使得电子应用的DNA复合体具有更高的导电性.

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科学领域:

  • 分子生物学分子生物学
  • 凝聚物质物理学 凝聚物质物理学
  • 有机化学 有机化学

背景情况:

  • 了解分子电子结构是化学设计的关键.
  • 在DNA中,电荷移位跨越多个基,超过单个基对连贯性.
  • 最近邻基对相互作用显著影响DNA电荷传输.

研究的目的:

  • 为了研究最近邻基对相互作用对DNA电荷传输的影响.
  • 开发用于控制DNA电子结构的设计指南.
  • 为了增强DNA复杂体中的电荷移位和导电性.

主要方法:

  • 对DNA复合体的计算分析,主要是富含关氨酸-氨酸的.
  • 对最近邻基对相互作用的检查.
  • 状态电子密度的分析.
  • 开发基于序列的设计规则.

主要成果:

  • 操纵DNA序列可以显著改变导电量而不会改变分子组成.
  • 一组设计准则被推断为在长DNA复合体中保持高导电性.
  • 证明了20个基对的DNA序列,导电率超过1 × 10-3G0.

结论:

  • 依赖序列的相互作用对于控制DNA电荷传输至关重要.
  • 开发的指导方针有助于为电子应用设计DNA.
  • 通过战略序列设计,可以实现DNA的高导电性.