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Updated: Jun 20, 2026

Optimized LC-MS/MS Method for the High-throughput Analysis of Clinical Samples of Ivacaftor, Its Major Metabolites, and Lumacaftor in Biological Fluids of Cystic Fibrosis Patients
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Optimized LC-MS/MS Method for the High-throughput Analysis of Clinical Samples of Ivacaftor, Its Major Metabolites, and Lumacaftor in Biological Fluids of Cystic Fibrosis Patients

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卷度吸收微样采集用于光度分析:方法验证和稳定性评估

Elisa Milandri1, Roberta Di Lecce2, Chiara Pia Iattoni1

  • 1Research Group of Pharmaco-Toxicological Analysis (PTA Lab), Department of Pharmacy and Biotechnology (FaBiT), Alma Mater Studiorum - University of Bologna, Via Belmeloro 6, 40126, Bologna, Italy.

Analytical and bioanalytical chemistry
|November 18, 2025
PubMed
概括

这项研究引入了一种新的微量采样方法,用于分析抗精神病药物卢马特佩龙. 这种方法支持治疗药物监测 (TDM) 以实现个性化精神病治疗,改善患者的坚持和减少副作用.

关键词:
在HPLCMS/MS/MS中使用.一个是Lumateperone.方法开发和验证方法的发展和验证.微量采样是指微量采样.固体相提取 (SPE) 是一种卷度吸收微采样 (VAMS) 是一种微采样技术.

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