左心室扩张对双心室功能和降低射出分数糖尿病中变形的影响:一个CMR特征跟踪研究
Wen-Rong Li1, Rui Shi1, Hua-Yan Xu2
1Department of Radiology, West China Hospital, Sichuan University, 37# Guo Xue Xiang, Chengdu, 610041, Sichuan, China.
Cardiovascular diabetology
|November 19, 2025
概括
糖尿病患者的左心室扩张,减少排泄分数与双心室功能受损有关. 这项研究强调了LV扩张作为与减少左心室全球周围应变相关的独立因素.
科学领域:
- 心脏病学 心脏病学
- 糖尿病学 糖尿病学
- 医疗成像医学成像
背景情况:
- 左心室 (LV) 扩张与左心室喷射分数 (LVEF) 减少的患者的预后不佳有关.
- LV扩张对降低LVEF的糖尿病 (DM) 患者双心室肌肉功能的影响尚不清楚.
- 了解这种关系对于治疗糖尿病患者心血管并发症至关重要.
研究的目的:
- 为了研究 LV 扩张和双心室肌肉功能障碍之间的关系,在糖尿病患者中减少 LVEF.
- 根据LVEF和LV扩张,在不同组糖尿病患者中比较心肌张力参数.
- 在这个人群中确定双心室功能障碍的独立预测因子.
主要方法:
- 心脏磁共振成像 (CMR) 被用于评估265名糖尿病患者.
- 患者被分为三个组:具有保存LVEF的DM (DMpEF),具有减少LVEF且没有LV扩张的DM (DMrEF-NLVD) 和具有扩张心肌病的DM (DMrEF-DCM).
- 使用多变量线性回归,评估和分析了双状应变参数 (全球辐射,周边和纵向应变).
主要成果:
- 在这三个组中观察到双心室菌株参数的显著差异.
- 全球LV菌株从DMpEF逐渐下降到DMrEF-NLVD和DMrEF-DCM组 (p < 0.001).
- 在减少LVEF (β = 0.176,p = 0.009) 的DM患者中,LV扩张独立地与减少LV全球周围应变 (LVGCS) 相关.
结论:
- 在糖尿病患者中,LVEF扩张与双心脏功能障碍和变形损伤有关,LVEF减少.
- 在这个患者队列中,LV扩张是LVGCS受损的独立预测因子.
- 这些发现强调了评估心力衰竭糖尿病患者的LV尺寸的重要性.
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