含有金属的纳米颗粒对人类健康的潜在不利影响:一个范围审查
Robert S Miller1, Robert Goodnough1, Timur S Durrani2
1Division of Toxicology, Department of Emergency Medicine, UT Health San Antonio, San Antonio, TX, USA.
Journal of occupational medicine and toxicology (London, England)
|November 19, 2025
概括
人类对金属纳米颗粒的暴露正在增加. 这篇评论强调了它们的毒性机制,主要是氧化应激和炎症,影响呼吸系统和神经系统等器官.
科学领域:
- 纳米毒理学研究
- 环境健康 环境健康
- 材料科学 材料科学 材料科学
背景情况:
- 人类对来自工业和消费产品的纳米粒子暴露的增加.
- 纳米粒子表现出独特的特性,导致新的毒理效应,主要是氧化应激和炎症.
- 由于这些新出现的风险,纳米毒理学是一个关键的公共卫生领域.
研究的目的:
- 综合来自临床前模型关于含金属纳米粒子毒性的证据.
- 提供与纳米粒子暴露相关的机制和末端器官毒性概述.
- 为纳米粒子风险评估提供公共卫生策略的信息.
主要方法:
- 根据PRISMA-ScR指南进行了范围审查.
- 搜索了PubMed关于纳米粒子吸入,人类毒性和金属的研究.
- 包括体内或体外人体组织研究,但不包括纯动物或评论文章.
主要成果:
- 分析了136篇文章,重点关注呼吸系统,胃肠道和免疫系统.
- 二氧化和氧化是研究最多的纳米粒子.
- 关键的毒性机制包括反应性氧物种生成,炎症,上皮屏障破坏和基因毒性.
结论:
- 纳米颗粒的毒性取决于物理化学性质 (大小,组成,聚合).
- 试验室模型是有价值的,但在标准化和临床翻译方面存在局限性.
- 未来的研究需要可重复的模型,混合暴露研究和敏感的生物标志物来更好地评估风险.
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