精子DNA碎片化对辅助生殖技术中胚胎繁殖率的影响:系统性审查和元分析
Bangbei Wan1,2, Yu Fu3, Ning Ma3
1Reproductive Medical Center, Hainan Women and Children's Medical Center, No. 75, Longkun South Road, Haikou, Hainan, China. 939313612@qq.com.
European journal of medical research
|November 19, 2025
概括
30%以上的高精子DNA碎片化 (SDF) 与辅助生殖技术 (ART) 周期中较少的幼胚胎有关. 这表明精子DNA完整性对胚胎染色体正常性的值效应.
科学领域:
- 生殖医学 生殖医学
- 遗传学 是一个遗传学.
- 不孕症研究 不孕症研究
背景情况:
- 精子DNA碎片化 (SDF) 是男性不孕不育的潜在指标.
- 它与辅助生殖技术 (ART) 中胚胎繁殖的关联需要进一步澄清.
研究的目的:
- 在ART周期中量化评估SDF和胚胎euploidy率之间的联系.
- 评估SDF水平是否会影响获得染色体正常胚胎的可能性.
主要方法:
- 按照PRISMA 2020指南进行系统审查和元分析.
- 搜索了主要的数据库 (PubMed,科学网,Embase,Scopus,Cochrane) 至2025年8月.
- 包括对IVF/ICSI周期的研究,其中测量了SDF和PGT-A对euploidy.
主要成果:
- 分析了6项研究 (1,516个周期),所有这些研究都使用精子染色素结构测定 (SCSA).
- 在15%的切割值下,高SDF和胚胎euploidy之间没有发现显著的关联.
- SDF ≥30%与较低的胚胎化率 (OR=0.742,95% CI 0.558-0.988) 有意义地相关.
结论:
- 高SDF (>30%) 与获得euploid胚胎的机会降低有关.
- 研究结果表明,精子DNA完整性对胚胎染色体正常性的影响取决于值.
- SDF评估可能有利于选择不育的夫妇,特别是那些有复发性ART衰竭或晚年孕产妇的夫妇.
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