Shaofei Zhao1, Balakrishna Hosmane2, Chen Chen3

  • 1Data and Statistical Sciences, AbbVie, North Chicago, IL, USA.

概括

这项研究引入了一种新的盲目的方法,用于估计使用交叉设计的药物生物等价性试验中的样本大小. 该方法通过在中间分析期间准确估计主体内部变异来提高统计能力.

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