口腔平坦和系统性疾病
S Warnakulasuriya1,2, P Ramos-García3,4, M Á González-Moles3,4
1Faculty of Dental, Oral & Craniofacial Sciences, King's College London, London, UK.
Journal of dental research
|November 19, 2025
概括
口腔平坦菌与许多系统性疾病有关,包括糖尿病,甲状腺疾病和精神健康状况. 认识到这些联系对于全面的患者护理和管理潜在的健康风险至关重要.
科学领域:
- 口腔医学是指口腔医学.
- 皮肤病学 皮肤病学
- 内部医学 内部医学
- 公共卫生 公共卫生
背景情况:
- 口腔平坦 (OLP) 是口腔粘膜的流行自身免疫性疾病,具有恶性潜力.
- 口腔作为整体健康状况的指标,反映了全身状况.
- 对管理患者健康的医疗保健专业人员来说,了解OLP并发症至关重要.
研究的目的:
- 批判性地审查口腔平坦菌与各种系统性疾病之间的并发症.
- 突出OLP患者对特定系统性疾病的倾向性增加.
- 为医疗保健提供者提供有关这些协会对患者管理和一般健康的影响的信息.
主要方法:
- 对口腔平坦的并发病现有研究进行系统审查.
- 对相关系统性疾病的聚合比例 (PP) 和几率比率 (OR) 的元分析.
- 统计分析以确定观察到的关联的显著性 (P值).
主要成果:
- 患有OLP的患者显著倾向于糖尿病 (PP=9.77%,OR=1.64),哈希莫托甲状腺炎 (PP=8.60%,OR=2.2),甲状腺功能低下 (PP=8.14%,OR=1.65) 和甲状腺功能过高 (PP=2.84%,OR=2.11).
- 发现与乳病 (PP=7.14%,OR=4.09),型肝炎 (PP=7.14%,OR=4.09),脂肪肝炎 (PP=7.06%,OR=5.71) 和肝硬化 (PP=4.27%,OR=5.8) 有强烈的关联.
- 还确定了与抑郁症 (PP=31.19%,OR=6.15),焦虑 (PP=54.76%,OR=3.51) 和压力 (PP=41.10%,OR=3.64) 的重要联系.
- 一些系统性疾病,如糖尿病,可能会导致OLP的发展.
- 这些并发症增加了肝脏,甲状腺,小肠和口腔癌的风险.
结论:
- 与普通人群相比,患有OLP的患者患全身性疾病的患病率和风险更高.
- 对于初级保健医生,牙医和口腔健康专业人员来说,对这些并发症的认识至关重要.
- 建议进行进一步的研究,以阐明这些相互联系的疾病的病理生物学和临床管理策略.
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