儿童和青少年急性淋巴细胞白血病幸存者的身体功能报告和肺功能缺陷:全国横截面ALL-STAR肺部研究
Sonja Izquierdo Riis Meyer1,2, Mette Tiedemann Skipper2,3, Birgitte Klug Albertsen2,3
1Department of Paediatrics and Adolescent Medicine, Danish Centre of Paediatric Pulmonology and Allergology, Aarhus University Hospital, Aarhus, Denmark.
Pediatric pulmonology
|November 19, 2025
概括
儿童急性淋巴细胞白血病 (ALL) 幸存者接受高风险 (HR) 化疗或干细胞移植 (HR-SCT) 报告身体功能较差. 肺功能缺陷 (PFD) 和异常的支气管扩展剂反应 (+BDR) 对年轻的幸存者产生影响,需要量身定制的随访.
科学领域:
- 儿科瘤学 儿科瘤学
- 肺部病理学 肺部病理学
- 康复医学 康复医学 康复医学
背景情况:
- 儿童急性淋巴细胞白血病 (ALL) 幸存者患肺功能缺陷 (PFD) 的风险增加.
- PFD可以对所有幸存者的身体功能产生负面影响.
- 这项研究评估了与PFD和异常支气管扩展剂反应 (+BDR) 相关的身体功能.
研究的目的:
- 为了评估父母代理和自我报告的童年身体功能,与对照组相比,所有幸存者.
- 确定PFD,+BDR和ALL幸存者的身体功能之间的关联.
- 在所有幸存者中识别身体功能受损的风险因素.
主要方法:
- 一项横截面研究包括184名ALL幸存者 (5-17.9岁) 和207名对照.
- 使用儿科生活质量库存 (PedsQL) 测量身体功能.
- 肺功能测试 (PFTs) 确定了PFD和+BDR;回归分析比较了组.
主要成果:
- 所有幸存者,特别是那些接受高风险 (HR) 化疗或干细胞移植 (HR-SCT) 治疗的人,报告说身体功能明显差.
- PFD/+BDR与年轻的幸存者 (5-15岁) 的身体功能较差有关,影响了跑步和体育等活动.
- 在幸存者组中,PFD/+BDR与身体功能报告没有相关性.
结论:
- 所有幸存者的身体功能缺陷与治疗强度 (HR和HR-SCT) 有关.
- PFD和+BDR显著影响年轻幸存者的身体功能.
- 对客观PFT测量和主观报告的平行评估对于高风险ALL幸存者的有效后续和干预至关重要.
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