通过患者状态指数 (PSi) 测量麻醉的深度与在电治疗期间增加发作持续时间无关
Pether Jildenstål1,2,3,4,5,6, Axel Nordenskjöld7, Måns Edström3
1Department of Health Sciences, Lund University, Lund, Sweden.
Acta anaesthesiologica Scandinavica
|November 19, 2025
概括
这项研究没有发现前患者状态指数 (PSi) 和电疗法 (ECT) 发作持续时间之间的联系. 因此,PSI可能无法用于指导ECT麻醉深度.
科学领域:
- 麻醉学 麻醉学
- 神经生理学 神经生理学
- 临床神经生理学 临床神经生理学
背景情况:
- 在电疗法 (ECT) 中,发作的持续时间与治疗的有效性有关.
- 在ECT期间监测麻醉深度至关重要,处理的基于EEG的患者状态指数 (PSi) 是一个潜在的工具.
- 这项研究研究了前触发性PSI和EEG发作持续时间之间的关系.
研究的目的:
- 为了确定前冲击患者状态指数 (PSi) 是否与在接受ECT的患者中脑电图 (EEG) 发作持续时间相关.
- 评估PSI在ECT期间指导麻醉深度的潜在临床实用性.
主要方法:
- 一项前性观察性研究,涉及瑞典一所大学医院接受常规ECT的成年患者.
- 使用SedLine处理EEG (pEEG) 系统进行监测,临床团队对PSI值进行了盲目监测.
- 统计分析使用了线性混合效应模型来评估前冲击PSi和EEG发作持续时间之间的关联,并对共变量进行调整.
主要成果:
- 对87次ECT疗程的分析显示,PSI从基线显著下降到前冲击值 (中位数为94至38).
- 在前冲击性PSI和EEG发作持续时间之间没有发现显著的相关性.
- 年龄和性别并没有显著地影响到前触发前的PSI,尽管基线PSI在性别之间有所不同.
结论:
- 在ECT中,脑电图发作前患者状态指数 (PSi) 与脑电图发作持续时间无关.
- 这些发现挑战了PSI在优化麻醉深度和指导ECT施用方面的临床实用性.
- 可能需要进一步的研究来探索其他EEG衍生措施来监测ECT深度.
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