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Updated: May 12, 2026

Nucleoside Triphosphates - From Synthesis to Biochemical Characterization
15:22

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Published on: April 3, 2014

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通过连续的2',2'-二化二胺的结合增强了i-动机的稳定性

Arnau Domínguez1,2,3, Cristina Cabrero4, Irene Gómez-Pinto4

  • 1Department of Surfactants and Nanobiotechnology, Institute for Advanced Chemistry of Catalonia (IQAC-CSIC), Jordi Girona 18-26, Barcelona, 08034, Spain.

Chemistry (Weinheim an der Bergstrasse, Germany)
|November 19, 2025
PubMed
概括

吉姆西塔 (dFdC) 修改增强了DNA i-动机结构的稳定性,特别是当多个连续的残留物被纳入时. 这些发现表明,dFdC可以用于为生物技术和疗法设计更强大的i-motifs.

关键词:
这就是I-motif.核磁共振结构NMR结构的修改 的修改这种药物是 gemcitabine.热稳定性的热稳定性

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Regioselective O-Glycosylation of Nucleosides via the Temporary 2',3'-Diol Protection by a Boronic Ester for the Synthesis of Disaccharide Nucleosides08:46

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Heterocyclic amines, where the N atom is a part of an alicyclic system, are similar in basicity to alkylamines. Interestingly, the heterocyclic amine having a nitrogen atom as part of an aromatic ring has much less basicity than its corresponding alicyclic counterpart. For this reason, as presented in Figure 1, piperidine (pKb = 2.8) is significantly more basic than pyridine (pKb = 8.8).
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The Hofmann and Curtius rearrangement reactions can be applied to synthesize primary amines from carboxylic acid derivatives such as amides and acyl azides. In the Hofmann rearrangement, a primary amide undergoes deprotonation in the presence of a base, followed by halogenation to generate an N-haloamide. A second proton abstraction produces a stabilized anionic species, which rearranges to an isocyanate intermediate via an alkyl group migration from the carbonyl carbon to the neighboring...
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