性别特异性差异和基于临床和生化参数的预测模型,用于最小肝脑病变
Juan José Gallego1,2, Franc Casanova-Ferrer1, Alessandra Fiorillo1
1INCLIVA Biomedical Research Institute, Valencia, Spain.
性别对肝硬化患者的肝脏脑病变 (MHE) 有很小的影响. 男人表现出更高的炎症和氧化应激. 性别特定的模型改善了MHE诊断,帮助早期干预肝脏脑病变的早期阶段.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 神经学 神经学
- 生物化学 生物化学
背景情况:
- 最小的肝脑病变 (MHE) 影响了30-40%的肝硬化患者,导致认知和运动缺陷.
- MHE是肝脏脑病变的最早阶段,这种情况具有严重的后果.
- 了解MHE的性别差异可以改善早期诊断和治疗.
研究的目的:
- 调查性对MHE的影响.
- 开发使用临床和生化参数的MHE性别特定的诊断方法.
主要方法:
- 在612名肝硬化患者和167名对照人群中进行了截面研究.
- 使用心理测量肝脏脑病评分的MHE分类.
- 收集临床,生化,认知,运动,氨,炎症和氧化应激数据.
主要成果:
- 在MHE的认知和运动障碍在两性之间是相似的.
- 与MHE女性相比,MHE男性表现出更高的炎症,氧化应激和肝病严重性标志物.
- 性别特定的多变量模型准确预测了MHE风险 (75%-81%的特异性,75%-79%的灵敏性).
结论:
- 性别是MHE发展和进展的一个重要因素.
- 将性别纳入MHE诊断和治疗策略至关重要.
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