亚洲早期胰腺癌负担的加快:使用GBD 2021进行32年全球比较分析
Xiaoxin Ye1,2, MingMing Jiang3, Shimin Chen1,2
1Medical School of Chinese People's Liberation Army, Beijing, China.
International journal of surgery (London, England)
|November 19, 2025
概括
早期胰腺癌 (EOPC) 负担在全球范围内不断增加,特别是在亚洲. 这一趋势凸显了针对高风险群体采取有针对性的公共卫生干预措施的必要性,以扭转不断上升的EOPC率.
科学领域:
- 流行病学 流行病学
- 在瘤学瘤学.
- 公共卫生 公共卫生
背景情况:
- 1990-2021年早期发生的胰腺癌 (EOPC) 的定量化年龄,性别和地理分层趋势.
- 研究了全球人口,社会人口统计指数 (SDI) 地区和高负担的亚洲国家.
研究的目的:
- 分析EOPC的致命和非致命负担的趋势.
- 在EOPC中识别人口,地理和风险因素差异.
主要方法:
- 使用的全球疾病负担 (GBD) 2021年数据.
- 使用死亡率,发病率和根据残疾调整的寿命年 (DALYs) 来量化EOPC负担.
- 用员工的joinpoint回归来计算EOPC负担的平均年度百分比变化 (AAPC).
主要成果:
- 在2021年,EOPC在全球造成了31531例新增病例和26996例死亡.
- EOPC负担呈上升趋势,高SDI地区负担较高,东亚,特别是中国和印度的贡献不成比例.
- 与普通胰腺癌不同,高空腹血葡萄糖 (FPG) 不是EOPC的主要风险因素;年龄和男性性别是显著的风险因素.
结论:
- EOPC的负担一直在稳步增加,人口和地理差异很大.
- 对于高风险人群,迫切需要精确的公共卫生干预措施.
- 减轻EOPC在亚洲和发展中国家的负担对于扭转全球趋势至关重要.
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