用于生物综合应用的可生物降解粘合剂系统
Won Bae Han1,2, Sungkeun Han1, Prashant Shivaji Shewale1
1KU-KIST Graduate School of Converging Science and Technology, Korea University, Seoul, 02841, Republic of Korea.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
|November 19, 2025
概括
可生物降解的粘合剂与组织结合并自然降解,避免去除和炎症. 本综述探讨了用于先进生物医学应用的五种粘附策略.
科学领域:
- 生物材料科学 生物材料科学
- 聚合物化学 聚合物化学
- 组织工程是组织工程.
背景情况:
- 传统的粘合剂需要拆除,可能会引起炎症和并发症.
- 可生物降解的粘合剂提供暂时的组织结合和自然降解.
- 关键应用包括伤口关闭,内部密封和生物电子集成.
研究的目的:
- 审查生物降解粘合剂的最新进展.
- 根据它们的粘附机制来对这些粘合剂进行分类.
- 讨论临床翻译的挑战和未来方向.
主要方法:
- 基于机制的框架来分类粘附策略.
- 分析了五个关键的粘附机制:物理互锁,键,甲基醇化学,氨基-碳基合和共键.
- 突出代表性材料系统及其属性.
主要成果:
- 详细检查生物降解粘合剂的五种不同的粘合策略.
- 在潮湿和生理条件下表现出强烈的,符合形状的粘附.
- 确定每个策略的特定材料系统及其功能性质.
结论:
- 可生物降解的粘合剂在临时生物医学应用中显示出显著的前景.
- 需要进一步的研究来应对临床翻译方面的挑战.
- 未来的方向包括开发智能,多功能生物粘合剂.
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