意想不到检测到的甲醇在向城市急诊室呈现的患者中的影响
Solana R Archuleta1, Jon B Cole1,2, Anita P Wong3
1Department of Emergency Medicine, Hennepin Healthcare, Minneapolis, MN, USA.
Clinical toxicology (Philadelphia, Pa.)
|November 19, 2025
概括
意外的阳性甲醇度不常见,通常不需要治疗. 临床怀疑仍然是确定显著甲醇暴露的关键,因为偶然发现不太可能具有临床意义.
科学领域:
- 临床毒理学 临床毒理学
- 紧急医疗 紧急医疗
- 分析化学 分析化学
背景情况:
- 甲醇中毒可能会出现非特异性症状,使得早期诊断具有挑战性.
- 意外检测到的甲醇水平的患病率和临床意义尚未得到充分确立.
研究的目的:
- 为了确定城市急诊室中意外阳性甲醇度的频率.
- 评估这些偶然的甲醇发现的临床意义.
主要方法:
- 对可检测甲醇度的患者进行回顾性队列研究 (2015-2022).
- 气相色谱与头空间采样用于同时测试乙醇和甲醇.
- 预期与意想不到的阳性甲醇结果的比较.
主要成果:
- 在1868个甲醇测试中,101个 (6%) 呈阳性. 其中47个是意想不到的.
- 意想不到的阳性的甲醇度中位数为50 mg/L,明显低于预期的阳性 (80 mg/L).
- 没有任何患者有意想不到的阳性甲醇检测结果需要特殊治疗.
结论:
- 意外阳性甲醇度很少见,通常没有临床意义.
- 临床怀疑和患者病史足以确定临床相关的甲醇暴露.
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