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代谢功能障碍相关的脂肪性肝病 (MASLD):机制,临床影响和治疗进展

Dalia M Miller¹, Kiana F McCauley², Kimberly J Dunham-Snary^1,3

¹Department of Medicine, Queen's University, Kingston, Ontario, Canada.

Endocrinology, diabetes & metabolism

|November 19, 2025

概括

代谢功能障碍相关的脂肪性肝病 (MASLD) 是一个日益严重的全球健康问题,影响着数百万人. 了解其机制和改进治疗方法对于管理这种复杂的肝脏疾病至关重要.

科学领域:

肝病学肝病学是一种肝病学.
代谢障碍代谢障碍代谢障碍
分子生物学分子生物学

背景情况:

代谢功能障碍相关的性肝病 (MASLD) 是最常见的慢性肝病,影响全球25-30%的成年人.
MASLD的患病率正在上升,特别是在肥胖和2型糖尿病患者中,男性比女性更容易受到影响.
疾病的谱系从简单的肥胖症到肝硬化,由于异质的进展和有限的治疗方法,这给临床管理带来了挑战.

研究的目的:

综合有关MASLD的当前文献,涵盖流行病学,病理生理学,临床表现和治疗.
检查驱动MASLD向代谢功能障碍相关的脂肪肝炎 (MASH) 的进展的关键分子机制.
审查诊断工具,风险分层以及MASLD的当前/新兴疗法.

主要方法:

流行病学数据,分子机制,临床表现和治疗策略的文献综合.
在MASLD中对脂质代谢,胰岛素抵抗和线粒体功能障碍的集中检查.
对诊断进步,风险分层和治疗方式的审查,包括生活方式,药理学和微生物组向方法.

主要成果:

MASLD是一种复杂的多因素疾病,由代谢综合征驱动,线粒体功能障碍起着关键作用.
关键的分子通路包括脂质失调,胰岛素抵抗和线粒体功能障碍,影响MASH的进展.
当前文献强调诊断局限性,疾病异质性和护理差异是持续存在的挑战.

结论:

线粒体功能障碍是MASLD病原体的核心,将遗传因素,代谢压力和炎症联系起来.
有效的管理需要解决MASLD的多因素性质及其与代谢综合征的联系.
结合线粒体贡献的临床前模型对于开发个性化的MASLD疗法至关重要.

关键词:

西式饮食方式的饮食.线粒体功能障碍相关的脂肪肝炎 (MASH)线粒体功能障碍相关的脂肪性肝病 (MASLD)线粒体遗传学线粒体遗传学

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