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Updated: Jan 11, 2026

Investigating the Spreading and Toxicity of Prion-like Proteins Using the Metazoan Model Organism C. elegans
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Investigating the Spreading and Toxicity of Prion-like Proteins Using the Metazoan Model Organism C. elegans

Published on: January 8, 2015

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具有改变RNA结合和降解活性的病理PNPase变体会影响细菌和人类细胞模型的表型

Roberto Pizzoccheri1, Federica A Falchi1, Andrea Alloni1

  • 1Dipartimento di Bioscienze, Università degli Studi di Milano, via Celoria 26, Milano 20133, Italy.

NAR molecular medicine
|November 19, 2025
PubMed
概括

人类多核酸酶 (hPNPase) 基因中的致病突变会导致严重的遗传疾病. 虽然细菌模型显示功能均丧失,但人类细胞模型显示了与疾病严重程度相关的突变特异性反应.

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