左半球在面部选择性激活和功能连接中的异常,在发育性前视觉症中的功能连接
Alison Campbell1,2, Xian Li1,3,4, David Rothlein1,5
1Boston Attention and Learning Laboratory, VA Boston Healthcare System, Boston, MA, United States.
Imaging neuroscience (Cambridge, Mass.)
|November 19, 2025
概括
发育前 (DP) 与左侧状面部区域 (FFA) 的大脑活化减少有关. 面部网络中的功能连接缺陷,特别是涉及右前上 (aSTS) 和左FFA,也在DP患者中观察到.
科学领域:
- 神经科学是一个神经科学.
- 认知神经科学 认知神经科学
- 神经成像是一种神经成像.
背景情况:
- 发育前视 (developmental prosopagnosia,简称DP) 是一种表现为无法识别熟悉面孔的疾病.
- 底层神经机制的DP还没有完全理解,这阻碍了识别必要的脑部区域正常的面部识别.
研究的目的:
- 通过使用fMRI来研究PD患者面部选择性大脑区域的功能激活和连接.
- 通过检查本地激活和网络连接来探索DP的神经基础.
主要方法:
- 在大量DP患者 (N=34) 和对照人群 (N=23) 上进行了fMRI扫描.
- 分析包括在面部观看期间的功能激活和休息期间的功能连接,检查面部选择性区域及其与其他皮质区域的连接.
主要成果:
- 在PD患者的左形面部区域 (FFA) 和左面部区域 (OFA) 发现面部选择性激活减少.
- 脸部网络中的功能连接在DP中减少,右前上 (aSTS) 和左FFA之间存在显著的缺陷.
- 在直接的面部选择网络之外,没有发现任何显著的功能连接差异.
结论:
- 左边的FFA在DP中观察到的面部识别缺陷中发挥了关键作用,影响了本地激活和网络连接.
- 在DP中,功能连接障碍在很大程度上局限于核心面处理网络.
- 这些发现凸显了左侧FFA及其网络相互作用在典型人脸识别中的重要性.
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