相关实验视频
Updated: Jan 11, 2026

09:15
Electrochemiluminescence Assays for Human Islet Autoantibodies
Published on: March 23, 2018
16.0K
甲状腺自身免疫在1型糖尿病发病时作为甲状腺功能障碍的预测因素:一项30年后期纵向研究
Gemma Carreras1,2,3, Lilian C Mendoza3,4,5,6, Cristina Colom3,4,7
1Department of Pediatrics, Hospital Santa Creu i Sant Pau, Barcelona, Spain.
Frontiers in endocrinology
|November 19, 2025
概括
在1型糖尿病发病时,甲状腺过氧化酶抗体 (TPO-Abs) 预测甲状腺功能障碍,特别是在成年人中. 查策略应纳入TPO-Abs和甲状腺激素水平,以实现最佳的患者管理.
科学领域:
- 内分泌学 在内分泌学.
- 免疫学 免疫学 免疫学
- 糖尿病研究 糖尿病研究
背景情况:
- 甲状腺自身免疫经常与1型糖尿病同时发生,这是由于共同的自身免疫路径.
- 早期发现甲状腺功能障碍对于管理1型糖尿病的代谢控制至关重要.
- 1型糖尿病患者甲状腺疾病的最佳查策略仍在争论中.
研究的目的:
- 评估甲状腺过氧化酶抗体 (TPO-Abs) 在1型糖尿病诊断后对随后的甲状腺功能障碍的长期预测价值.
- 评估1型糖尿病发病时年龄对甲状腺功能障碍发展的影响.
主要方法:
- 对160名被诊断患有1型糖尿病的高加索患者进行了回顾性纵向研究 (1987-1994).
- 随访时间至少10年 (平均30.6年),定期评估甲状腺功能.
- 在诊断时测量TPO-Abs;根据TPO-Ab状态和发病时的年龄分层分析 (<18 vs. ≥18岁).
主要成果:
- 21.9%的患者在诊断时呈TPO-Abs阳性.
- TPO-Ab阳性显著增加了甲状腺功能障碍的风险 (RR 8.1,p<0.001).
- 甲状腺功能障碍发生在抗体阴性患者中,特别是那些在18岁之前被诊断出来的人. 与TPO-Abs相关的风险在成年人中比年轻人 (RR 3.4) 高 (RR 12.6).
结论:
- 推的查包括TPO-Abs和thyotropin在无症状的1型糖尿病患者的诊断时.
- 建议每年对抗体阳性个体进行甲状腺激素监测.
- 对于在18岁之前被诊断出抗体阴性患者,建议从青春期到成年期每两年进行一次查.
相关概念视频
Diabetes Mellitus: Overview and Type I Subtype
4.8K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
4.8K
Autoimmune Disorders
1.4K
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
Concept and Mechanism of Autoimmune Diseases
The immune...
1.4K
Diabetes: Symptoms, Diagnosis, and Complications
2.0K
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
2.0K
Diabetes Mellitus: Type 2 and Gestational
4.3K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
4.3K
Pathophysiology of Diabetes
3.1K
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
3.1K
Psychoneuroimmunology: Diabetes and Cancer
417
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
417

